Publications, Reviews, Books, Patents, Theses

Peer-reviewed papers (ISI listed journals)

2023

Personne, Hippolyte; Paschoud, Thierry; Fulgencio, Sofia; Baeriswyl, Stéphane; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2023). To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide. Journal of medicinal chemistry, 66(11), S. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460

2021

Baeriswyl, Stéphane; Personne, Hippolyte; Di Bonaventura, Ivan; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2021). A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography.Journal of medicinal chemistry, 66(11), S. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460

Aeschimann, Walter; Kammer, Stephan; Staats, Stefanie; Schneider, Petra; Schneider, Gisbert; Rimbach, Gerald; Cascella, Michele; Stocker, Achim (2021). Engineering of a functional γ-tocopherol transfer protein. Redox biology, 38, S. 101773. Elsevier 10.1016/j.redox.2020.101773

2019

Baeriswyl, Stéphane; Gan, Bee Ha; Siriwardena, Thissa N.; Visini, Ricardo; Robadey, Maurane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes. ACS Chemical Biology, 14(4), S. 758-766. American Chemical Society 10.1021/acschembio.9b00047

Baeriswyl, Stéphane; Javor, Sacha; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2019). X‐Ray Crystal Structure of a Second‐Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB. Helvetica chimica acta, 102(9) Wiley 10.1002/hlca.201900178

2018

Bermúdez, Luisa; Del Pozo, Talía; Silvestre Lira, Bruno; de Godoy, Fabiana; Boos, Irene; Romanò, Cecilia; Previtali, Viola; Almeida, Juliana; Bréhélin, Claire; Asis, Ramón; Quadrana, Leandro; Demarco, Diego; Alseekh, Saleh; Salinas Gamboa, Rigel; Pérez-Flores, Laura; Dominguez, Pia Guadalupe; Rothan, Christophe; Fernie, Alisdair Robert; González, Maurício; Stocker, Achim; Hemmerle Andreas; Clausen, Mads Hartving; Carrari Fernando; Rossi Magdalena (2018). A Tomato Tocopherol-Binding Protein Sheds Light on Intracellular α-Tocopherol Metabolism in Plants. Plant & cell physiology, 59(11), S. 2188-2203. Oxford Academic 10.1093/pcp/pcy191

Peltzer, Raphael Mathias; Kolli, Hima Bindu; Stocker, Achim; Cascella, Michele (2018). Self-Assembly of α-Tocopherol Transfer Protein Nanoparticles: A Patchy Protein Model. The Journal of Physical Chemistry B, 122(28), S. 7066-7072. American Chemical Society 10.1021/acs.jpcb.8b05936

2017

Runze He, Ivan Di Bonaventura, Ricardo Visini, Bee-Ha Gan, Yongchun Fu, Daniel Probst, Alexandre Lüscher, Thilo Köhler,  Christian van Delden, Achim Stocker, Wenjing Hong, Tamis Darbre and Jean-Louis Reymond (2017). Design, crystal structure and atomic force microscopy study of thioether ligated d,l-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa. Chemical Science, 8(11):7464-7475. doi:10.1039/c7sc01599b.

Ivan Di Bonaventura, Xian Jin,a  Ricardo Visini, Daniel Probst, Sacha Javor, Bee-Ha Gan, Gaëlle Michaud, Antonino Natalello,  Silvia Maria Doglia, Thilo Köhler, Christian van Delden, Achim Stocker, Tamis Darbre and Jean-Louis Reymond (2017).
Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms.
Chemical Science, 8(10):6784-6798. doi:10.1039/c7sc01314k.

Aeschimann, Walter; Staats, Stefanie; Kammer, Stephan Martin; Olieric, Natacha; Jeckelmann, Jean-Marc; Fotiadis, Dimitrios José; Netscher, Thomas; Rimbach, Gerald; Cascella, Michele; Stocker, Achim (2017). Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier. Scientific Reports, 7(1) Nature Publishing Group 10.1038/s41598-017-05148-9

2016

Probst, Markus; Aeschimann, Walter; Chau, Thi T H; Langenegger, Simon Matthias; Stocker, Achim; Häner, Robert (2016). Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease. Nucleic acids research, 44(15), S. 7079-7089. Information Retrieval Ltd. 10.1093/nar/gkw644

Röthlisberger, Pascal; Istrate, Alena; Marcaida Lopez, M. J.; Visini, Ricardo; Stocker, Achim; Reymond, Jean-Louis; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chemical communications, 52(26), S. 4749-4752. Royal Society of Chemistry 10.1039/c6cc00374e

Michaud, Gaëlle; Visini, Ricardo; Bergmann, Myriam; Salerno, Gianluca; Bosco, Rosa; Gillon, Emilie; Richichi, Barbara; Nativi, Cristina; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2016). Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. Chemical Science, 7(1), S. 166-182. The Royal Society of Chemistry 10.1039/c5sc03635f

2015

Bergmann, Myriam; Michaud, Gaëlle; Visini, Ricardo; Jin, Xian; Gillon, Emilie; Stocker, Achim; Imberty, Anne; Darbre, Tamis; Reymond, Jean-Louis (2015). Multivalency effects in Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Organic & biomolecular chemistry, 14(1), S. 138-148. Royal Society of Chemistry 10.1039/C5OB01682G

Wagner, Anika; Piegholdt, Stefanie; Rabe, Doerte; Baenas, Nieves; Schloesser, Anke; Eggersdorfer, Manfred; Stocker, Achim; Rimbach, Gerald (2015). Epigallocatechin gallate (EGCG) affects glucose metabolism and enhances fitness and life span in Drosophila melanogaster. OncoTarget, 6(31), S. 30568-30578. Impact Journals LLC 10.18632/oncotarget.5215

Visini, Ricardo; Bergmann, Myriam; Michaud, Gaelle; Pertici, Francesca; Fu, Ou; Pukin, Aliaksei; Branson, Thomas; Thies-Weesie, Dominique; Kemmink, Johan; Gillon, Emilie; Imberty, Anne; Stocker, Achim; Darbre, Tamis; Pieters, Roland; Reymond, Jean-Louis (2015). Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeroginosa lectin LecA. ACS Chemical Biology, 10(11), S. 2455-2462. American Chemical Society 10.1021/acschembio.5b00302

Lamprakis, Christos; Stocker, Achim; Cascella, Michele (2015). Mechanisms of recognition and binding of α-TTP to the plasma membrane by multi-scale molecular dynamics simulations. Frontiers in Molecular Biosciences, 2(36) Frontiers 10.3389/fmolb.2015.00036

Christen, Monika; Marcaida, Maria; Lamprakis, Christos; Aeschimann, Walter; Vaithilingam, Jathana; Schneider, Petra; Hilbert, Manuel; Schneider, Gisbert; Cascella, Michele; Stocker, Achim (2015). Evidence for direct squalene and 2,3-oxidosqualene binding by supernatant protein factor. Journal of structural biology, 190(190), S. 261-270. Elsevier 10.1016/j.jsb.2015.05.001

2014

Helbling, R.E.; Lamprakis, C.; Aeschimann, W.; Bolze, C.; Stocker, A. and Cascella, M. (2014): Mechanisms of ligand-protein interaction in Sec-14 like transporters investigated by computer simulations. CHIMIA 68:615-619.

Bartoloni, M., Waltersperger, S., Bumann, M., Stocker, A., Darbre, T. and Reymond, J-L. (2014): Stereoselective synthesis and structure determination of a bicycle[3.3.2]deca-peptide. ARKIVOC 113-123.

Bolze, CS., Helbling, RE., Owen, RL., Pearson, AR., Pompidor, G., Dworkowski, F., Fuchs, M., Furrer, J., Golczak, G., Palczewski, K., Cascella, M. and Stocker, A. (2014): Human Cellular Retinaldehyde Binding Protein Has Secondary Thermal 9-cis-Retinal Isomerase Activity. JACS 136(1), 137-146.

2013

Kadam, RU., Bergmann, M., Garg, D., Gabrieli, G., Stocker, A., Darbre T. and Reymond J-L. (2013): Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chem. Eur. J. 19, 17054-17063.

Helbling, RE., Bolze, CS., Golczak, G., Palczewski, K., Stocker, A.* and Cascella M.* (2013): Cellular retinaldehyde binding protein – Different binding modes and microsolvation patterns for high affinity 9-cis and 11-cis-retinal substrates. J Phys Chem B 117(37), 10719-10729.

Kadam, UR., Garg, D., Vasnia, R., Sattler, M., Stocker, A., Darbre, T. and Reymond, JL. (2013): CH-π “T-shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA. ACS Chem Biol. 8, 1925-1930.

2012

Helbling, RE., Aeschimann, W., Simona, F., Stocker, A.,* Cascella, M.* (2012): Engineering tocopherol selectivity in α-TTP: a combined in vitro/in silico study. PLoS One. 7(11), e49195.

2011

Kadam RU, Bergmann M, Hurley M, Garg D, Cacciarini M, Swiderska MA, Nativi C, Sattler M, Smyth AR, Williams P, Cámara M, Stocker A, Darbre T, Reymond JL. (2011): A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms. Angew Chem Int Ed Engl. 50, 10631-5.

2010 and before

Ernst IM, Wagner AE, Schuemann C, Storm N, Höppner W, Döring F, Stocker A, Rimbach G. (2010): Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts. Pharmacol Res. 63, 233-40.

He X, Lobsiger J, Stocker A. (2009): Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W. Proc Natl Acad Sci 106, 18545-50.

Stocker, A., Keis, S., Vonck, J., Cook, G. M., and Dimroth, P. (2007): The structural basis for unidirectional rotation of thermoalkaliphilic F1-ATPase. Structure15, 904-14.

Keis, S., Stocker, A., Dimroth, P., and Cook, G. M. (2006): Inhibition of ATP hydrolysis by thermoalkaliphilic F1Fo-ATP synthase is controlled by the C terminus of the epsilon subunit. J Bacteriol 188, 3796-804.

Stocker, A., Keis, S., Cook, G. M., and Dimroth, P. (2005): Purification, crystallization, and properties of F1-ATPase complexes from the thermoalkaliphilic Bacillus sp. strain TA2.A1. J Struct Biol 152, 140-5.

Morley, S., Panagabko, C., Shineman, D., Mani, B., Stocker, A., Atkinson, J., and Manor, D. (2004): Molecular determinants of heritable vitamin E deficiency. Biochemistry 43, 4143-9.

Stocker, A., and Baumann, U. (2003): Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis. J Mol Biol 332, 759-65.

Meier, R., Tomizaki, T., Schulze-Briese, C., Baumann, U., and Stocker, A. (2003): The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol 331, 725-34.

Stocker A, Tomizaki T, Schulze-Briese C and Baumann U (2002): Crystal Structure of the Human Supernatant Protein Factor. Structure 10, 1533-1540.

Azzi A, Aratri E, Boscoboinik D, Clement S, Ozer N, Ricciarelli R, Spycher S, Stocker A (2001): Vitamins and regulation of gene expression. Bibl Nutr Dieta 55, 177-188.

Azzi A, Breyer I, Feher M, Ricciarelli R, Stocker A, Zimmer S, Zingg J (2001): Nonantioxidant functions of alpha-tocopherol in smooth muscle cells. J Nutr 131, 378-381.

Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A (2000): A novel human tocopherol-associated protein: cloning, in-vitro expression and characterization. J Biol Chem 275, 25672-25680.

Stocker A, Zimmer S, Spycher SE, Azzi A (1999): Identification of a novel cytosolic tocopherol-binding protein: structure, specificity, and tissue distribution. IUBMB Life 48, 49-55.

Negri A, Buckmann AF, Tedeschi G, Stocker A, Ceciliani F, Treu C, Ronchi S (1999): Covalent flavinylation of L-aspartate oxidase from Escherichia coli using N6-(6-carboxyhexyl)-FAD succinimidoester. J Protein Chem 18, 671-6.

Azzi A, Boscoboinik D, Clement S, Ozer N, Ricciarelli R, Stocker A (1999): Vitamin E mediated response of smooth muscle cell to oxidant stress. Diabetes Res Clin Pract 45, 191-198.

Azzi A, Boscoboinik D, Clément S, Oezer NK, Ricciarelli R, Stocker A, Tasinato A and  Sirikci O (1997): Signalling Functions of a-Tocopherol in Smooth Muscle Cells. Internat J Vit Nutr Res 67, 343-349.

Bückmann AF, Wray V and Stocker A (1996): Synthesis of N6-(2-Aminoethyl)-FAD, N6-(6-Carboxyhexyl)-FAD, and related compounds. Methods Enzymol Part J. Vitamins and Coenzymes 280, 360-374.

Willner I, Blonder R, Stocker A, Bückmann AF and Katz E (1996): Reconstitution of Apo-Glucose Oxidase with a Nitrospiropyran-Modified FAD Cofactor Yields a Photoswitchable Biocatalyst for Amperometric Transduction of Recorded Optical Signals. JACS 118, 5310-5311.

Stocker A, Hecht HJ and Bückmann AF (1996): Synthesis, characterization and preliminary crystallographic data of N6-(6-carbamoylhexyl)-FAD-D-amino-acid oxidase from pig kidney, a semi-synthetic oxidase. Eur J Biochem 238, 519-528.

Stocker A, Fretz H, Frick H, Rüttimann A and Woggon WD (1996): The Substrate Specificity of Tocopherol Cyclase. Bioorganic and Medicinal Chemistry 4, 1129-1134.

Sztajer H, Wang W, Lünsdorf H, Stocker A and Schmid RD (1996): Purification and some properties of a novel microbial lactate oxidase. Appl. Microbiol. Biotechnol 45, 600-606.

Riklin, A.; Katz, E.; Willner, I.; Stocker, A.; Buckmann, A.F. (1996) Israel - Improving enzyme-electrode contacts. Biosensors and Bioelectronics, 11(4) pp. viii-viii. http://dx.doi.org/10.1016/0956-5663(96)82744-8

Riklin A, Katz E, Willner I, Stocker A and Bückmann AF (1995): Improving enzyme-electrode contacts by redox modification of cofactors. Nature 376, 672-675.

Matile S, Hansen T, Stocker A and Woggon WD (1994): ß-Cyclodextrin-Mediated Regioselective Hydrolysis of 5,10,15,20-Tertrakis [2,4-bis (pivaloyloxy) -21H-porphine]. Helv Chim Acta 77, 1087. 

Stocker A, Netscher T, Rüttimann A, Müller RK, Schneider H, Todaro LJ, Derungs G and Woggon WD (1994): The Reaction Mechanism of Chromanol-Ring Formation Catalyzed by Tocopherol Cyclase from Anabaena variabilis Kützing (Cyanobacteria). Helv Chim Acta77, 1720.

Stocker A, Rüttimann A and Woggon WD (1993): Identification of the Tocopherol-Cyclase in the Blue-Green Algae Anabaena variabilis Kützing (Cyanobacteria). Helv Chim Acta76, 1729.

Reviews

Cascella, M., Bärfuss, S., Stocker, A. (2013): Cis-Retinoids and the Chemistry of Vision. Archives of Biochemistry and Biophysics 539(2), 187-95.

Stocker, A. (2004): Molecular mechanisms of vitamin E transport. Ann N Y Acad Sci 1031, 44-59.

Morley, S., Panagabko, C., Stocker, A., Atkinson, J., and Manor, D. (2004): Structure-function relationship in the tocopherol transfer protein. Ann N Y Acad Sci 1031, 332-3.

Azzi, A., Aratri, E., Boscoboinik, D., Clement, S., Ozer, N., Ricciarelli, R., Spycher, S., and Stocker, A. (2001): Vitamins and regulation of gene expression. Bibl Nutr Dieta 177-88.

Azzi A, Stocker A (2000): Vitamin E: non-antioxidant roles. Prog Lipid Res 39, 231-255.

Stocker A, Azzi A (2000):Tocopherol-Binding Proteins: Their Function and Physiological Significance. Antioxidants & Redox Signaling 2, 397-404.

Azzi A, Breyer I, Feher M, Pastori M, Ricciarelli R, Spycher S, Staffieri M, Stocker A, Zimmer S, Zingg JM (2000): Specific cellular responses to alpha-tocopherol. J Nutr 130, 1649-1652.

Books

He, X., Lobsiger, J., Stocker, A. (2012): Molecular clues to Bothnia-Type retinitis Pigmentosa. Advances in Experimental Medicine and Biology 723, 589-594.

Oezer NK, Taha S, Stocker A, and Azzi A (1999): Effects of High Cholesterol, Vitamin E, and Probucol on Protein Kinase C Activity and Proliferation of Smooth Muscle Cells. Antioxidant Food Supplements in Human Health, ed. Lester Packer, Midori Hiramatsu and Toshikazu Yoshikawa. Academic Press, San Diego.

Oezer NK, Sirikci O, Taha S, Engin NK, Boscoboinik D, Clément S, Stocker A and Azzi A (1998): Prevention of Atherosclerosis by a-Tocopherol in Smooth Muscle Cells. Free Radicals, Oxidative Stress, and Antioxidants, ed. Oezben. Plenum Press, New York.

Patents

Stocker Achim (2017): Nanospheres of sec14-like proteins and cognate ligands. PCT Int. Appl. WO 2017129555 A1

Stocker A and Woggon WD (1990): Process for Producing Tocopherols. PCT Int. Appl. WO 9001554 A1, 23 pp. Patent.

Theses

Stocker, A. (2004): “Molecular mechanisms of vitamin E transport”. Habilitation Thesis, University of Bern, Switzerland.
Stocker, A. (1996): “Identification and Isolation of the Tocopherol-Cyclase of Anabaena-Variabilis Kützing (Cyanobacteria)”. PhD Thesis, University of Zürich, Switzerland.
Stocker, A. (1986): “Differential Chemical Modification of Cytochrome-c”. Diploma Thesis, University of Zürich, Switzerland.